Volume 1 Issue 2
June  2022
Turn off MathJax
Article Contents
Yonghai Feng, Funing Chen, Jessica M Rosenholm, Lei Liu, Hongbo Zhang. Efficient nanozyme engineering for antibacterial therapy[J]. Materials Futures, 2022, 1(2): 023502. doi: 10.1088/2752-5724/ac7068
Citation: Yonghai Feng, Funing Chen, Jessica M Rosenholm, Lei Liu, Hongbo Zhang. Efficient nanozyme engineering for antibacterial therapy[J]. Materials Futures, 2022, 1(2): 023502. doi: 10.1088/2752-5724/ac7068
Perspective •
OPEN ACCESS

Efficient nanozyme engineering for antibacterial therapy

© 2022 The Author(s). Published by IOP Publishing Ltd on behalf of the Songshan Lake Materials Laboratory
Materials Futures , Volume 1, Number 2
  • Received Date: 2022-04-18
  • Accepted Date: 2022-05-16
  • Publish Date: 2022-06-28
  • Antimicrobial resistance (AMR) poses a huge threat to human health. It is urgent to explore efficient ways to suppress the spread of AMR. Antibacterial nanozymes have become one of the powerful weapons to combat AMR due to their enzyme-like catalytic activity with a broad-spectrum antibacterial performance. However, the inherent low catalytic activity of nanozymes limits their expansion into antibacterial applications. In this regard, a variety of advanced chemical design strategies have been developed to improve the antimicrobial activity of nanozymes. In this review, we have summarized the recent progress of advanced strategies to engineer efficient nanozymes for fighting against AMR, which can be mainly classified as catalytic activity improvement, external stimuli, bacterial affinity enhancement, and multifunctional platform construction according to the basic principles of engineering efficient nanocatalysts and the mechanism of nanozyme catalysis. Moreover, the deep insights into the effects of these enhancing strategies on the nanozyme structures and properties are highlighted. Finally, current challenges and future perspectives of antibacterial nanozymes are discussed for their future clinical potential.

  • loading
  • [1]
    Antimicrobial Resistance Collaborators 2022 Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis Lancet 399 629–55
    [2]
    Tian R et al 2022 Synergistic antibiosis with spatiotemporal controllability based on multiple-responsive hydrogel for infectious cutaneous wound healing Smart Mater. Med. 3 304–14
    [3]
    Shang Z, Chan S Y, Song Q, Li P and Huang W 2020 The strategies of pathogen-oriented therapy on circumventing antimicrobial resistance Research 2020 2016201
    [4]
    Baker S, Thomson N, Weill F-X and Holt K E 2018 Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens Science 360 733–8
    [5]
    Wu P, Chen D, Yang H, Lai C, Xuan C, Chen Y and Shi X 2021 Antibacterial peptide-modified collagen nanosheet for infected wound repair Smart Mater. Med. 2 172–81
    [6]
    S¸en Karaman D, Ercan U K, Bakay E, Topalo˘glu N and Rosenholm J M 2020 Evolving technologies and strategies for combating antibacterial resistance in the advent of the postantibiotic era Adv. Funct. Mater. 30 1908783
    [7]
    Gao F, Shao T, Yu Y, Xiong Y and Yang L 2021 Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action Nat. Commun. 12 745
    [8]
    Bi X et al 2022 Boron doped graphdiyne: a metal-free peroxidase mimetic nanozyme for antibacterial application Nano Res. 15 1446–54
    [9]
    Mei L, Zhu S, Liu Y, Yin W, Gu Z and Zhao Y 2021 An overview of the use of nanozymes in antibacterial applications Chem. Eng. J. 418 129431
    [10]
    Gao L et al 2007 Intrinsic peroxidase-like activity of ferromagnetic nanoparticles Nat. Nanotechnol. 2 577–83
    [11]
    Wei H, Gao L, Fan K, Liu J, He J, Qu X, Dong S, Wang E and Yan X 2021 Nanozymes: a clear definition with fuzzy edges Nano Today 40 101269
    [12]
    Zhang R, Yan X and Fan K 2021 Nanozymes inspired by natural enzymes Acc. Mater. Res. 2 534–47
    [13]
    Zhu D, Chen H, Huang C, Li G, Wang X, Jiang W and Fan K 2022 H2O2 self-producing single-atom nanozyme hydrogels as light-controlled oxidative stress amplifier for enhanced synergistic therapy by transforming “cold” tumors Adv. Funct. Mater. 32 2110268
    [14]
    Wang X, Zhong X, Liu Z and Cheng L 2020 Recent progress of chemodynamic therapy-induced combination cancer therapy Nano Today 35 100946
    [15]
    Hong C, Meng X, He J, Fan K and Yan X 2022 Nanozyme: a promising tool from clinical diagnosis and environmental monitoring to wastewater treatment Particuology 71 90–107
    [16]
    Wang Q, Jiang J and Gao L 2022 Catalytic antimicrobial therapy using nanozymes WIREs Nanomed. Nanobiotechnol. 14 e1769
    [17]
    Tang G, He J, Liu J, Yan X and Fan K 2021 Nanozyme for tumor therapy: surface modification matters Exploration 1 75–89
    [18]
    Wang Z, Zhang R, Yan X and Fan K 2020 Structure and activity of nanozymes: inspirations for de novo design of nanozymes Mater. Today 41 81–119
    [19]
    Mirhosseini M, Shekari-Far A, Hakimian F, Haghiralsadat B F, Fatemi S K and Dashtestani F 2020 Core-shell Au@Co-Fe hybrid nanoparticles as peroxidase mimetic nanozyme for antibacterial application Process Biochem. 95 131–8
    [20]
    Hu W-C, Younis M R, Zhou Y, Wang C and Xia X-H 2020 In situ fabrication of ultrasmall gold nanoparticles/2D MOFs hybrid as nanozyme for antibacterial therapy Small 16 2000553
    [21]
    Wang Z, Dong K, Liu Z, Zhang Y, Chen Z, Sun H, Ren J and Qu X 2017 Activation of biologically relevant levels of reactive oxygen species by Au/g-C3N4 hybrid nanozyme for bacteria killing and wound disinfection Biomaterials 113 145–57
    [22]
    Liao X, Xu Q, Sun H, Liu W, Chen Y, Xia X-H and Wang C 2022 Plasmonic nanozymes: localized surface plasmonic resonance regulates reaction kinetics and antibacterial performance J. Phys. Chem. Lett. 13 312–23
    [23]
    Zhong Y, Wang T, Lao Z, Lu M, Liang S, Cui X, Li Q-L and Zhao S 2021 Au-Au/IrO2@Cu(PABA) reactor with tandem enzyme-mimicking catalytic activity for organic dye degradation and antibacterial application ACS Appl. Mater. Interfaces 13 21680–92
    [24]
    Mu Q, Sun Y, Guo A, Xu X, Qin B and Cai A 2021 A bifunctionalized NiCo2O4-Au composite: intrinsic peroxidase and oxidase catalytic activities for killing bacteria and disinfecting wound J. Hazard. Mater. 402 123939
    [25]
    Xu Q, Liao X, Hu W, Liu W and Wang C 2021 Plasmon induced dual excited synergistic effect in Au/metal–organic frameworks composite for enhanced antibacterial therapy J. Mater. Chem. B 9 9606–14
    [26]
    Yan L et al 2021 Gold nanoplates with superb photothermal efficiency and peroxidase-like activity for rapid and synergistic antibacterial therapy Chem. Commun. 57 1133–6
    [27]
    Fan Y, Gan X, Zhao H, Zeng Z, You W and Quan X 2022 Multiple application of SAzyme based on carbon nitride nanorod-supported Pt single-atom for H2O2 detection, antibiotic detection and antibacterial therapy Chem. Eng. J. 427 131572
    [28]
    Xi J, Wei G, An L, Xu Z, Xu Z, Fan L and Gao L 2019 Copper/carbon hybrid nanozyme: tuning catalytic activity by the copper state for antibacterial therapy Nano Lett. 19 7645–54
    [29]
    Yim G, Kim C Y, Kang S, Min D-H, Kang K and Jang H 2020 Intrinsic peroxidase-mimicking Ir nanoplates for nanozymatic anticancer and antibacterial treatment ACS Appl. Mater. Interfaces 12 41062–70
    [30]
    Cao C et al 2022 POD nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy Signal Transduct. Target 7 86
    [31]
    Lu C, Tang L, Gao F, Li Y, Liu J and Zheng J 2021 DNA-encoded bimetallic Au-Pt dumbbell nanozyme for high-performance detection and eradication of E. coli O157:H7 Biosens. Bioelectron. 187 113327
    [32]
    Zhang S, Lu Q, Wang F, Xiao Z, He L, He D and Deng L 2021 Gold–platinum nanodots with high-peroxidase-like activity and photothermal conversion efficiency for antibacterial therapy ACS Appl. Mater. Interfaces 13 37535–44
    [33]
    Niu J, Zhao C, Liu C, Ren J and Qu X 2021 Bio-inspired bimetallic enzyme mimics as bio-orthogonal catalysts for enhanced bacterial capture and inhibition Chem. Mater. 33 8052–8
    [34]
    Sun D et al 2020 Ultrasound-switchable nanozyme augments sonodynamic therapy against multidrug-resistant bacterial infection ACS Nano 14 2063–76
    [35]
    Zhu Z et al 2022 Plasmon-enhanced peroxidase-like activity of nitrogen-doped graphdiyne oxide quantum dots/gold–silver nanocage heterostructures for antimicrobial applications Chem. Mater. 34 1356–68
    [36]
    Xiao J, Hai L, Li Y, Li H, Gong M, Wang Z, Tang Z, Deng L and He D 2022 An ultrasmall Fe3O4-decorated polydopamine hybrid nanozyme enables continuous conversion of oxygen into toxic hydroxyl radical via GSH-depleted cascade redox reactions for intensive wound disinfection Small 18 2105465
    [37]
    He Y, Chen X, Zhang Y, Wang Y, Cui M, Li G, Liu X and Fan H 2022 Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles Sci. China Life Sci. 65 184–92
    [38]
    Vallabani N V S, Vinu A, Singh S and Karakoti A 2020 Tuning the ATP-triggered pro-oxidant activity of iron oxide-based nanozyme towards an efficient antibacterial strategy J. Colloid Interface Sci. 567 154–64
    [39]
    Karim M N et al 2018 Visible-light-triggered reactive-oxygen-species-mediated antibacterial activity of peroxidase-mimic CuO nanorods ACS Appl. Nano Mater. 1 1694–704
    [40]
    Chishti B, Fouad H, Seo H K, Alothman O Y, Ansari Z A and Ansari S G 2020 ATP fosters the tuning of nanostructured CeO2 peroxidase-like activity for promising antibacterial performance New J. Chem. 44 11291–303
    [41]
    Ma W, Zhang T, Li R, Niu Y, Yang X, Liu J, Xu Y and Li C M 2020 Bienzymatic synergism of vanadium oxide nanodots to efficiently eradicate drug-resistant bacteria during wound healing in vivo J. Colloid Interface Sci. 559 313–23
    [42]
    Wang Y, Chen C, Zhang D and Wang J 2020 Bifunctionalized novel Co-V MMO nanowires: intrinsic oxidase and peroxidase like catalytic activities for antibacterial application Appl. Catal. B 261 118256
    [43]
    Cao F, Zhang L, Wang H, You Y, Wang Y, Gao N, Ren J and Qu X 2019 Defect-rich adhesive nanozymes as efficient antibiotics for enhanced bacterial inhibition Angew. Chem., Int. Ed. 58 16236–42
    [44]
    Ma D, Xie C, Wang T, Mei L, Zhang X, Guo Z and Yin W 2020 Liquid-phase exfoliation and functionalization of MoS2 nanosheets for effective antibacterial application ChemBioChem 21 2373–80
    [45]
    Lin Y, Liu X, Liu Z and Xu Y 2021 Visible-light-driven photocatalysis-enhanced nanozyme of TiO2 nanotubes@MoS2 nanoflowers for efficient wound healing infected with multidrug-resistant bacteria Small 17 2103348
    [46]
    Luo Q, Li J, Wang W, Li Y, Li Y, Huo X, Li J and Wang N 2022 Transition metal engineering of molybdenum disulfide nanozyme for biomimicking anti-biofouling in seawater ACS Appl. Mater. Interfaces 14 14218–25
    [47]
    Ali S R and De M 2021 Thiolated ligand-functionalized MoS2 nanosheets for peroxidase-like activities ACS Appl. Nano Mater. 4 12682–9
    [48]
    Wang X et al 2020 Biodegradable nickel disulfide nanozymes with GSH-depleting function for high-efficiency photothermal-catalytic antibacterial therapy iScience 23 101281
    [49]
    Xi J, Zhang J, Qian X, An L and Fan L 2020 Using a visible light-triggered pH switch to activate nanozymes for antibacterial treatment RSC Adv. 10 909–13
    [50]
    Bai Q et al 2022 Plasmonic nanozyme of graphdiyne nanowalls wrapped hollow copper sulfide nanocubes for rapid bacteria-killing Adv. Funct. Mater. 32 2112683
    [51]
    Xie Y, Qian Y, Li Z, Liang Z, Liu W, Yang D and Qiu X 2021 Near-infrared-activated efficient bacteria-killing by lignin-based copper sulfide nanocomposites with an enhanced photothermal effect and peroxidase-like activity ACS Sustain. Chem. Eng. 9 6479–88
    [52]
    Mo S, Song Y, Lin M, Wang J, Zhang Z, Sun J, Guo D and Liu L 2022 Near-infrared responsive sulfur vacancy-rich CuS nanosheets for efficient antibacterial activity via synergistic photothermal and photodynamic pathways J. Colloid Interface Sci. 608 2896–906
    [53]
    Wang J, Wang Y, Zhang D and Chen C 2020 Intrinsic oxidase-like nanoenzyme Co4S3/Co(OH)2 hybrid nanotubes with broad-spectrum antibacterial activity ACS Appl. Mater. Interfaces 12 29614–24
    [54]
    Xiu W et al 2020 Biofilm microenvironment-responsive nanotheranostics for dual-mode imaging and hypoxia-relief-enhanced photodynamic therapy of bacterial infections Research 2020 9426453
    [55]
    Xi J, Wei G, Wu Q, Xu Z, Liu Y, Han J, Fan L and Gao L 2019 Light-enhanced sponge-like carbon nanozyme used for synergetic antibacterial therapy Biomater. Sci. 7 4131–41
    [56]
    Tripathi K M, Ahn H T, Chung M, Le X A, Saini D, Bhati A, Sonkar S K, Kim M I and Kim T 2020 N, S, and P-Co-doped carbon quantum dots: intrinsic peroxidase activity in a wide ph range and its antibacterial applications ACS Biomater. Sci. Eng. 6 5527–37
    [57]
    Liu Y, Xu B, Lu M, Li S, Guo J, Chen F, Xiong X, Yin Z, Liu H and Zhou D 2022 Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing Bioactive Mater. 12 246–56
    [58]
    Zhang L, Liu Z, Deng Q, Sang Y, Dong K, Ren J and Qu X 2021 Nature-inspired construction of MOF@COF nanozyme with active sites in tailored microenvironment and pseudopodia-like surface for enhanced bacterial inhibition Angew. Chem., Int. Ed. 60 3469–74
    [59]
    Liu Z, Wang F, Ren J and Qu X 2019 A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria Biomaterials 208 21–31
    [60]
    Zhang S, Yang Z, Hao J, Ding F, Li Z and Ren X 2022 Hollow nanosphere-doped bacterial cellulose and polypropylene wound dressings: biomimetic nanocatalyst mediated antibacterial therapy Chem. Eng. J. 432 134309
    [61]
    Feng Y, Qin J, Zhou Y, Yue Q and Wei J 2022 Spherical mesoporous Fe-N-C single-atom nanozyme for photothermal and catalytic synergistic antibacterial therapy J. Colloid Interface Sci. 606 826–36
    [62]
    Huang L, Chen J, Gan L, Wang J and Dong S 2019 Single-atom nanozymes Sci. Adv. 5 eaav5490
    [63]
    Huo M, Wang L, Zhang H, Zhang L, Chen Y and Shi J 2019 Construction of single-iron-atom nanocatalysts for highly efficient catalytic antibiotics Small 15 1901834
    [64]
    Wang X, Shi Q, Zha Z, Zhu D, Zheng L, Shi L, Wei X, Lian L, Wu K and Cheng L 2021 Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy Bioactive Mater. 6 4389–401
    [65]
    Zhao Y et al 2021 A highly accessible copper single-atom catalyst for wound antibacterial application Nano Res. 14 4808–13
    [66]
    Xu B et al 2019 A single-atom nanozyme for wound disinfection applications Angew. Chem., Int. Ed. 58 4911–6
    [67]
    Yu Y et al 2022 Theory-screened MOF-based single-atom catalysts for facile and effective therapy of biofilm-induced periodontitis Chem. Eng. J. 431 133279
    [68]
    Jiang D, Ni D, Rosenkrans Z T, Huang P, Yan X and Cai W 2019 Nanozyme: new horizons for responsive biomedical applications Chem. Soc. Rev. 48 3683–704
    [69]
    Wu W, Huang L, Wang E and Dong S 2020 Atomic engineering of single-atom nanozymes for enzyme-like catalysis Chem. Sci. 11 9741–56
    [70]
    Sang Y, Li W, Liu H, Zhang L, Wang H, Liu Z, Ren J and Qu X 2019 Construction of nanozyme-hydrogel for enhanced capture and elimination of bacteria Adv. Funct. Mater. 29 1900518
    [71]
    Huang Y, Ren J and Qu X 2019 Nanozymes: classification, catalytic mechanisms, activity regulation, and applications Chem. Rev. 119 4357–412
    [72]
    Wei M, Lee J, Xia F, Lin P, Hu X, Li F and Ling D 2021 Chemical design of nanozymes for biomedical applications Acta Biomater. 126 15–30
    [73]
    Lu X, Gao S, Lin H, Yu L, Han Y, Zhu P, Bao W, Yao H, Chen Y and Shi J 2020 Bioinspired copper single-atom catalysts for tumor parallel catalytic therapy Adv. Mater. 32 2002246
    [74]
    Kim M S, Lee J, Kim H S, Cho A, Shim K H, Le T N, An S S A, Han J W, Kim M I and Lee J 2020 Heme cofactor-resembling Fe–N single site embedded graphene as nanozymes to selectively detect H2O2 with high sensitivity Adv. Funct. Mater. 30 1905410
    [75]
    Ensign A A, Jo I, Yildirim I, Krauss T D and Bren K L 2008 Zinc porphyrin: a fluorescent acceptor in studies of Zn-cytochrome c unfolding by fluorescence resonance energy transfer Proc. Natl Acad. Sci. USA 105 10779–84
    [76]
    Ducros V, Brzozowski A M, Wilson K S, Brown S H, Østergaard P, Schneider P, Yaver D S, Pedersen A H and Davies G J 1998 Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 Å resolution Nat. Struct. Biol. 5 310–6
    [77]
    Liao J J-L 2007 Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors J. Med. Chem. 50 409–24
    [78]
    Tao Y, Ju E, Ren J and Qu X 2015 Bifunctionalized mesoporous silica-supported gold nanoparticles: intrinsic oxidase and peroxidase catalytic activities for antibacterial applications Adv. Mater. 27 1097–104
    [79]
    Chang M, Hou Z, Wang M, Yang C, Wang R, Li F, Liu D, Peng T, Li C and Lin J 2021 Single-atom Pd nanozyme for ferroptosis-boosted mild-temperature photothermal therapy Angew. Chem., Int. Ed. 60 12971–9
    [80]
    Jiao L et al 2020 Densely isolated FeN4 sites for peroxidase mimicking ACS Catal. 10 6422–9
    [81]
    Wang L et al 2020 Defect-rich adhesive molybdenum disulfide/rGO vertical heterostructures with enhanced nanozyme activity for smart bacterial killing application Adv. Mater. 32 2005423
    [82]
    Wei F, Cui X, Wang Z, Dong C, Li J and Han X 2021 Recoverable peroxidase-like Fe3O4@MoS2-Ag nanozyme with enhanced antibacterial ability Chem. Eng. J. 408 127240
    [83]
    Liu Y, Nie N, Tang H, Zhang C, Chen K, Wang W and Liu J 2021 Effective antibacterial activity of degradable copper-doped phosphate-based glass nanozymes ACS Appl. Mater. Interfaces 13 11631–45
    [84]
    Li D, Guo Q, Ding L, Zhang W, Cheng L, Wang Y, Xu Z, Wang H and Gao L 2020 Bimetallic CuCo2S4 nanozymes with enhanced peroxidase activity at neutral pH for combating burn infections ChemBioChem 21 2620–7
    [85]
    Xia X, Zhang J, Lu N, Kim M J, Ghale K, Xu Y, McKenzie E, Liu J and Ye H 2015 Pd–Ir core–shell nanocubes: a type of highly efficient and versatile peroxidase mimic ACS Nano 9 9994–10004
    [86]
    Puvvada N, Panigrahi P K, Mandal D and Pathak A 2012 Shape dependent peroxidase mimetic activity towards oxidation of pyrogallol by H2O2 RSC Adv. 2 3270–3
    [87]
    He S, Huang J, Zhang Q, Zhao W, Xu Z and Zhang W 2021 Bamboo-like nanozyme based on nitrogen-doped carbon nanotubes encapsulating cobalt nanoparticles for wound antibacterial applications Adv. Funct. Mater. 31 2105198
    [88]
    Wang X, Zhong X, Zha Z, He G, Miao Z, Lei H, Luo Q, Zhang R, Liu Z and Cheng L 2020 Biodegradable CoS2 nanoclusters for photothermal-enhanced chemodynamic therapy Appl. Mater. Today 18 100464
    [89]
    Vallabani N V S, Singh S and Karakoti A S 2019 Investigating the role of ATP towards amplified peroxidase activity of iron oxide nanoparticles in different biologically relevant buffers Appl. Surf. Sci. 492 337–48
    [90]
    Chen L, Xing S, Lei Y, Chen Q, Zou Z, Quan K, Qing Z, Liu J and Yang R 2021 A glucose-powered activatable nanozyme breaking pH and H2O2 limitations for treating diabetic infections Angew. Chem., Int. Ed. 60 23534–9
    [91]
    Liu C, Zhang M, Geng H, Zhang P, Zheng Z, Zhou Y and He W 2021 NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing Appl. Catal. B 295 120317
    [92]
    Gao F, Li X, Zhang T, Ghosal A, Zhang G, Fan H M and Zhao L 2020 Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing J. Control. Release 324 598–609
    [93]
    Shi S et al 2018 Iron oxide nanozyme suppresses intracellular Salmonella Enteritidis growth and alleviates infection in vivo Theranostics 8 6149–62
    [94]
    Chen Z, Yin J-J, Zhou Y-T, Zhang Y, Song L, Song M, Hu S and Gu N 2012 Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity ACS Nano 6 4001–12
    [95]
    Wiegand C, Abel M, Ruth P, Elsner P and Hipler U C 2015 pH Influence on antibacterial efficacy of common antiseptic substances Skin Pharmacol. Phys. 28 147–58
    [96]
    Vallabani N V S, Karakoti A S and Singh S 2017 ATP-mediated intrinsic peroxidase-like activity of Fe3O4-based nanozyme: one step detection of blood glucose at physiological pH Colloids Surf. B 153 52–60
    [97]
    Lin Y, Huang Y, Ren J and Qu X 2014 Incorporating ATP into biomimetic catalysts for realizing exceptional enzymatic performance over a broad temperature range NPG Asia Mater. 6 e114
    [98]
    Xu C and Pu K 2021Second near-infrared photothermal materials for combinational nanotheranostics Chem. Soc. Rev. 50 1111–37
    [99]
    Qiang L, Jin H, Feng Y, Wu R, Song Y and Liu L 2021 Apoptosis-like bacterial death modulated by photoactive hyperthermia nanomaterials and enhanced wound disinfection application Nanoscale 13 14785–94
    [100]
    Feng Y, Chen Q, Yin Q, Pan G, Tu Z and Liu L 2019 Reduced graphene oxide functionalized with gold nanostar nanocomposites for synergistically killing bacteria through intrinsic antimicrobial activity and photothermal ablation ACS Appl. Bio Mater. 2 747–56
    [101]
    Chen Q, Zhang L, Feng Y, Shi F, Wang Y, Wang P and Liu L 2018 Dual-functional peptide conjugated gold nanorods for the detection and photothermal ablation of pathogenic bacteria J. Mater. Chem. B 6 7643–51
    [102]
    Liu Z, Zhao X, Yu B, Zhao N, Zhang C and Xu F-J 2021 Rough carbon–iron oxide nanohybrids for near-infrared-ii light-responsive synergistic antibacterial therapy ACS Nano 15 7482–90
    [103]
    Liu L, Pan X, Liu S, Hu Y and Ma D 2021 Near-infrared light-triggered nitric oxide release combined with low-temperature photothermal therapy for synergetic antibacterial and antifungal Smart Mater. Med. 2 302–13
    [104]
    Gui H, Feng Y, Qiang L, Sun T and Liu L 2021 Core/shell structural ultra-small gold and amyloid peptide nanocomposites with effective bacterial surface adherence and enhanced antibacterial photothermal ablation Smart Mater. Med. 2 46–55
    [105]
    Zhu X, Chen X, Jia Z, Huo D, Liu Y and Liu J 2021 Cationic chitosan@Ruthenium dioxide hybrid nanozymes for photothermal therapy enhancing ROS-mediated eradicating multidrug resistant bacterial infection J. Colloid Interface Sci. 603 615–32
    [106]
    Yin W, Yu J, Lv F, Yan L, Zheng L R, Gu Z and Zhao Y 2016 Functionalized nano-MoS2 with peroxidase catalytic and near-infrared photothermal activities for safe and synergetic wound antibacterial applications ACS Nano 10 11000–11
    [107]
    Wang X, Sun X, Bu T, Wang Q, Zhang H, Jia P, Li L and Wang L 2021 Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds Acta Biomater. 135 342–55
    [108]
    Craig L, Pique M E and Tainer J A 2004 Type IV pilus structure and bacterial pathogenicity Nat. Rev. Microbiol. 2 363–78
    [109]
    Song H, Ahmad Nor Y, Yu M, Yang Y, Zhang J, Zhang H, Xu C, Mitter N and Yu C 2016 Silica nanopollens enhance adhesion for long-term bacterial inhibition J. Am. Chem. Soc. 138 6455–62
    [110]
    Roberts R E and Hallett M B 2019 Neutrophil cell shape change: mechanism and signalling during cell spreading and phagocytosis Int. J. Mol. Sci. 20 1383
    [111]
    Shan J, Yang K, Xiu W, Qiu Q, Dai S, Yuwen L, Weng L, Teng Z and Wang L 2020 Cu2MoS4 nanozyme with NIR-II light enhanced catalytic activity for efficient eradication of multidrug-resistant bacteria Small 16 2001099
    [112]
    Zhang W, Ren X, Shi S, Li M, Liu L, Han X, Zhu W, Yue T, Sun J and Wang J 2020 Ionic silver-infused peroxidase-like metal–organic frameworks as versatile ‘antibiotic’ for enhanced bacterial elimination Nanoscale 12 16330–8
    [113]
    Huang T, Yu Z, Yuan B, Jiang L, Liu Y, Sun X, Liu P, Jiang W and Tang J 2022 Synergy of light-controlled Pd nanozymes with NO therapy for biofilm elimination and diabetic wound treatment acceleration Mater. Today Chem. 24 100831
    [114]
    Wang M et al 2022 Triple-synergistic MOF-nanozyme for efficient antibacterial treatment Bioactive Mater. 17 289–99
    [115]
    Nong W, Chen Y, Lv D, Yan Y, Zheng X, Shi X, Xu Z, Guan W, Wu J and Guan Y 2022 Metal-organic framework based nanozyme hybrid for synergistic bacterial eradication by lysozyme and light-triggered carvacrol release Chem. Eng. J. 431 134003
    [116]
    Du X, Jia B, Wang W, Zhang C, Liu X, Qu Y, Zhao M, Li W, Yang Y and Li Y-Q 2022 pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer J. Nanobiotechnol. 20 12
    [117]
    Zhang Y, Li D, Xu Y and Niu Y 2022 Application of a cascaded nanozyme in infected wound recovery of diabetic mice ACS Biomater. Sci. Eng. 8 1522−31
    [118]
    Li Y, Wang L, Liu H, Pan Y, Li C, Xie Z and Jing X 2021 Ionic covalent-organic framework nanozyme as effective cascade catalyst against bacterial wound infection Small 17 2100756
    [119]
    Guo G et al 2020 Space-selective chemodynamic therapy of CuFe5O8 nanocubes for implant-related infections ACS Nano 14 13391–405
    [120]
    Feng X, Hou X, Cui C, Sun S, Sadik S, Wu S and Zhou F 2021 Mechanical and antibacterial properties of tannic acid-encapsulated carboxymethyl chitosan/polyvinyl alcohol hydrogels Eng. Regen. 2 57–62
    [121]
    Wu H, Li F, Shao W, Gao J and Ling D 2019 Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel ACS Cent. Sci. 5 477–85
    [122]
    Li Y, Fu R, Duan Z, Zhu C and Fan D 2022 Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing Bioactive Mater. 9 461–74
    [123]
    Li Y, Yu P, Wen J, Sun H, Wang D, Liu J, Li J and Chu H 2022 Nanozyme-based stretchable hydrogel of low hysteresis with antibacterial and antioxidant dual functions for closely fitting and wound healing in movable parts Adv. Funct. Mater. 32 2110720
    [124]
    Jia Z, Lv X, Hou Y, Wang K, Ren F, Xu D, Wang Q, Fan K, Xie C and Lu X 2021 Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics Bioactive Mater. 6 2676–87
    [125]
    Li Y, Fu R, Duan Z, Zhu C and Fan D 2022 Adaptive hydrogels based on nanozyme with dual-enhanced triple enzyme-like activities for wound disinfection and mimicking antioxidant defense system Adv. Healthcare Mater. 11 2101849
    [126]
    Xu M et al 2020 Near-infrared-controlled nanoplatform exploiting photothermal promotion of peroxidase-like and oxd-like activities for potent antibacterial and anti-biofilm therapies ACS Appl. Mater. Interfaces 12 50260–74
    [127]
    Zhang Y, Li D, Tan J, Chang Z, Liu X, Ma W and Xu Y 2021 Near-infrared regulated nanozymatic/photothermal/photodynamic triple-therapy for combating multidrug-resistant bacterial infections via oxygen-vacancy molybdenum trioxide nanodots Small 17 2005739
    [128]
    Wang X, Sun X, Bu T, Wang Q, Jia P, Dong M and Wang L 2022 In situ fabrication of metal-organic framework derived hybrid nanozymes for enhanced nanozyme-photothermal therapy of bacteria-infected wounds Composites B 229 109465
    [129]
    Liao Z-Y et al 2022 Metal–organic framework modified MoS2 nanozyme for synergetic combating drug-resistant bacterial infections via photothermal effect and photodynamic modulated peroxidase-mimic activity Adv. Healthcare Mater. 11 2101698
    [130]
    Cheng H, Lin S, Muhammad F, Lin Y-W and Wei H 2016 Rationally modulate the oxidase-like activity of nanoceria for self-regulated bioassays ACS Sens. 1 1336–43
    [131]
    Shi W, Fan H, Ai S and Zhu L 2015 Honeycomb-like nitrogen-doped porous carbon supporting Pt nanoparticles as enzyme mimic for colorimetric detection of cholesterol Sens. Actuators B 221 1515–22
  • 加载中

Catalog

    Figures(1)

    Article Metrics

    Article Views(138) PDF downloads(12)
    Article Statistics
    Related articles from

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return