Volume 1 Issue 1
March  2021
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Zehao Chen, Zhendong Lv, Zhen Zhang, Yuhui Zhang, Wenguo Cui. Biomaterials for microfluidic technology[J]. Materials Futures, 2022, 1(1): 012401. doi: 10.1088/2752-5724/ac39ff
Citation: Zehao Chen, Zhendong Lv, Zhen Zhang, Yuhui Zhang, Wenguo Cui. Biomaterials for microfluidic technology[J]. Materials Futures, 2022, 1(1): 012401. doi: 10.1088/2752-5724/ac39ff
Topical Review •

Biomaterials for microfluidic technology

© 2022 The Author(s). Published by IOP Publishing Ltd on behalf of the Songshan Lake Materials Laboratory
Materials Futures , Volume 1, Number 1
  • Received Date: 2021-10-17
  • Accepted Date: 2021-11-15
  • Publish Date: 2022-01-12
  • Micro/nanomaterial-based drug and cell delivery systems play an important role in biomedical fields for their injectability and targeting. Microfluidics is a rapidly developing technology and has become a robust tool for preparing biomaterial micro/nanocarriers with precise structural control and high reproducibility. By flexibly designing microfluidic channels and manipulating fluid behavior, various forms of biomaterial carriers can be fabricated using microfluidics, including microspheres, nanoparticles and microfibers. In this review, recent advances in biomaterials for designing functional microfluidic vehicles are summarized. We introduce the application of natural materials such as polysaccharides and proteins as well as synthetic polymers in the production of microfluidic carriers. How the material properties determine the manufacture of carriers and the type of cargoes to be encapsulated is highlighted. Furthermore, the current limitations of microfluidic biomaterial carriers and perspectives on its future developments are presented.

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  • [1]
    Zheng Y, Wu G, Chen L, Zhang Y, Luo Y, Zheng Y, Hu F, Forouzanfar T, Lin H and Liu B 2021 Bioact. Mater. 6 627
    Yan Y F et al 2019 Biomaterials 190 97
    Lin J, Wang Z, Huang J, Tang S, Saiding Q, Zhu Q and Cui W 2021 Small 17 2007235
    Yang M, Li J, Gu P and Fan X 2021 Bioact. Mater. 6 1973
    Diba M, Koons G L, Bedell M L and Mikos A G 2021 Biomaterials 274 120871
    Li L, Yu M, Li Y, Li Q, Yang H, Zheng M, Han Y, Lu D, Lu S and Gui L 2021 Bioact. Mater. 6 1255
    Stromberg Z R et al 2021 Int. J. Pharm. 597 120340
    Zhao X, Bian F, Sun L, Cai L, Li L and Zhao Y 2020 Small 16 1901943
    Cai L, Bian F, Chen H, Guo J, Wang Y and Zhao Y 2021 Chem 7 93
    Chebil A, Funfschilling D, Léonard M, Six J-L, Nouvel C and Durand A 2018 ACS Appl. Bio Mater. 1 879
    Han Y et al 2021 Bioact. Mater. 6 3596
    Wu J Z, Li G, Ye T J, Lu G H, Li R M, Deng L F, Wang L, Cai M and Cui W G 2020 Chem. Eng. J. 393 124715
    Shang L, Cheng Y and Zhao Y 2017 Chem. Rev. 117 7964
    Matula K, Rivello F and Huck W T S 2020 Adv. Biosyst. 4 1900188
    Liu H, Cai Z W, Wang F, Hong L W, Deng L F, Zhong J, Wang Z T and Cui W G 2021 Adv. Sci. 8 2101619
    Sun H, Zheng H, Tang Q, Dong Y, Qu F, Wang Y, Yang G and Meng T 2019 ACS Appl. Mater. Interfaces 11 37313
    Mou C L, Wang W, Li Z L, Ju X J, Xie R, Deng N N, Wei J, Liu Z and Chu L Y 2018 Adv. Sci. 5 1700960
    Kamperman T, Teixeira L M, Salehi S S, Kerckhofs G, Guyot Y, Geven M, Geris L, Grijpma D, Blanquer S and Leijten J 2020 Lab Chip 20 490
    Yang J, Zhang X, Liu C, Wang Z, Deng L, Feng C, Tao W, Xu X and Cui W 2021 Prog. Mater. Sci. 118 100768
    Shepherd S J, Issadore D and Mitchell M J 2021 Biomaterials 274 120826
    Ahn J, Ko J, Lee S, Yu J, Kim Y and Jeon N L 2018 Adv. Drug Deliv. Rev. 128 29
    Niculescu A-G, Chircov C, Bˆırc˘a A C and Grumezescu A M 2021 Nanomaterials 11 864
    Zoqlam R, Morris C J, Akbar M, Alkilany A M, Hamdallah S I, Belton P and Qi S 2021 Mater. Sci. Eng. C 127 112243
    Hamdallah S I, Zoqlam R, Erfle P, Blyth M, Alkilany A M, Dietzel A and Qi S 2020 Int. J. Pharm. 584 119408
    Sun J et al 2015 Adv. Mater. 27 1402
    Zhao S et al 2021 Lab Chip 21 2453
    Bayareh M, Ashani M N and Usefian A 2020 Chem. Eng. Process. 147 107771
    Chen L, Zhang L, Zhang H, Sun X, Liu D, Zhang J, Zhang Y, Cheng L, Santos H A and Cui W 2021 Bioact. Mater. 6 3218
    Wu R and Kim T 2021 Lab Chip 21 1217
    Wang Z, Wang Y C, Yan J Q, Zhang K S, Lin F, Xiang L, Deng L F, Guan Z P, Cui W G and Zhang H B 2021 Adv. Drug Del. Rev. 174 504
    Daniele M A, Boyd D A, Adams A A and Ligler F S 2015 Adv. Healthcare Mater. 4 11
    Wang J, Shao C, Wang Y, Sun L and Zhao Y 2020 Engineering 6 1244
    Du X-Y, Li Q, Wu G and Chen S 2019 Adv. Mater. 31 1903733
    Jia L, Han F, Yang H, Turnbull G, Wang J, Clarke J, Shu W, Guo M and Li B 2019 Adv. Healthcare Mater. 8 1900435
    Chen F and Huang G 2018 Int. J. Biol. Macromol. 112 211
    Khunmanee S, Jeong Y and Park H 2017 J. Tissue Eng. 8 2041731417726464
    Chen Z J et al 2021 Adv. Sci. 8 2004793
    Sloan S R, Wipplinger C, Kirnaz S, Navarro-Ramirez R, Schmidt F, McCloskey D, Pannellini T, Schiavinato A, Hartl R and Bonassar L J 2020 Sci. Transl. Med. 12 eaay2380
    Labie H, Perro A, Lapeyre V, Goudeau B, Catargi B, Auzely R and Ravaine V 2019 J. Colloid Interface Sci. 535 16
    Zhai P S, Peng X X, Li B Q, Liu Y P, Sun H C and Li X W 2020 Int. J. Biol. Macromol. 151 1224
    Li X P, Cui T Y, Zhang W X, Zhai Z R, Wu F X, Zhang Y W, Yang M S, Zhong W Y and Yue W Q 2020 Colloid Surf. B 196 111281
    Bian L M, Guvendiren M, Mauck R L and Burdick J A 2013 Proc. Natl Acad. Sci. USA 110 10117
    Lin F, Wang Z, Xiang L, Deng L F and Cui W G 2021 Adv. Funct. Mater. 2107678
    Kim S, Yim S G, Chandrasekharan A, Seong K Y, Lee T W, Kim B, Kim K, Choi S and Yang S Y 2020 J. Control. Release 322 337
    Busatto C A, Labie H, Lapeyre V, Auzely-Velty R, Perro A, Casis N, Luna J, Estenoz D A and Ravaine V 2017 J. Colloid Interface Sci. 493 356
    Shendi D, Albrecht D R and Jain A 2017 J. Biomed. Mater. Res. A 105 608
    Mendes B B, Daly A C, Reis R L, Domingues R M A, Gomes M E and Burdick J A 2021 Acta Biomater. 119 101
    Dovedytis M, Liu Z J and Bartlett S 2020 Eng. Regen. 1 102
    Costa-Almeida R, Gasperini L, Borges J, Babo P S, Rodrigues M T, Mano J F, Reis R L and Gomes M E 2017 ACS Biomater. Sci. Eng. 3 1322
    Agnello S, Gasperini L, Reis R L, Mano J F, Pitarresi G, Palumbo F S and Giammona G 2016 Mater. Lett. 182 309
    Palumbo F S, Fiorica C, Pitarresi G, Zingales M, Bologna E and Giammona G 2018 Biomater. Sci. 6 2518
    Ching S H, Bansal N and Bhandari B 2017 Crit. Rev. Food Sci. Nutr. 57 1133
    Liu Y Z, Tottori N and Nisisako T 2019 Sens. Actuator B 283 802
    Zhang C, Grossier R, Lacaria L, Rico F, Candoni N and Veesler S 2020 Chem. Eng. Sci. 211 115322
    An C F et al 2020 Acta Biomater. 111 181
    Liu H-T, Wang H, Wei W-B, Liu H, Jiang L and Qin J-H 2018 Small 14 1801095
    Taemeh M A, Shiravandi A, Korayem M A and Daemi H 2020 Carbohydr. Polym. 228 115419
    Luken A, Geiger M, Steinbeck L, Joel A C, Lampert A, Linkhorst J and Wessling M 2021 Adv. Healthcare Mater. 10 2100898
    Liu M Y, Zhou Z Z, Chai Y C, Zhang S, Wu X M, Huang S P, Su J Q and Jiang J H 2017 Biofabrication 9 025030
    Chaurasia A S, Jahanzad F and Sajjadi S 2017 Chem. Eng. J. 308 1090
    Lee K Y and Mooney D J 2012 Prog. Polym. Sci. 37 106
    Wang S, Bruning A, Jeon O, Long F, Alsberg E and Choi C K 2018 Biomicrofluidics 12 014106
    Gao Y and Jin X 2019 Mar. Drugs 17 557
    Cui C, Sun S, Wu S, Chen S, Ma J and Zhou F 2021 Eng. Regener 2 82
    Pell´a M C G, Lima-Tenório M K, Tenório-Neto E T, Guilherme M R, Muniz E C and Rubira A F 2018 Carbohydr. Polym. 196 233
    Wang X H, Yan L, Ye T J, Cheng R Y, Tian J L, Ma C, Wang Y B and Cui W G 2019 Mater. Sci. Eng. C 102 415
    Zhuang Y and Cui W 2021 Adv. Drug Del. Rev. 176 113885
    He Z, Santos J L, Tian H, Huang H, Hu Y, Liu L, Leong K W, Chen Y and Mao H Q 2017 Biomaterials 130 28
    Moradikhah F, Doosti-Telgerd M, Shabani I, Soheili S, Dolatyar B and Seyedjafari E 2020 Life Sci. 254 117768
    Pessoa A C S N, Sipoli C C and de La Torre L G 2017 Lab Chip 17 2281
    Chiesa E, Greco A, Riva F, Tosca E M, Dorati R, Pisani S, Modena T, Conti B and Genta I 2019 Int. J. Mol. Sci. 20 6212
    Wang Y Q, Liu H T, Zhang M, Wang H, Chen W W and Qin J H 2020 Biomater. Sci. 8 5476
    Mohammadi H, Alihosseini F and Hosseini S A 2020 Int. J. Biol. Macromol. 164 3394
    Wang Y, Zhou J, Guo X, Hu Q, Qin C, Liu H, Dong M and Chen Y 2017 Mater. Sci. Eng. C 81 13
    He T, Wang W, Chen B, Wang J, Liang Q and Chen B 2020 Carbohydr. Polym. 236 116094
    Mu X-T, Ju X-J, Zhang L, Huang X-B, Faraj Y, Liu Z, Wang W, Xie R, Deng Y and Chu L-Y 2019 J. Membr. Sci. 590 117275
    Hu Q, Lu Y and Luo Y 2021 Carbohydr. Polym. 264 117999
    Chen F, Huang G and Huang H 2020 Int. J. Biol. Macromol. 145 827
    Zhou C, Zhu P, Tian Y, Tang X, Shi R and Wang L 2017 Lab Chip 17 3310
    Kamperman T, Henke S, Visser C W, Karperien M and Leijten J 2017 Small 13 1603711
    Liu D et al 2018 Adv. Mater. 30 1706032
    He C, Ji H, Qian Y, Wang Q, Liu X, Zhao W and Zhao C 2019 J. Mater. Chem. B 7 1186
    Lei Y et al 2021 Adv. Funct. Mater. 31 2105084
    Husman D et al 2020 Biomater. Sci. 8 101
    Siltanen C, Yaghoobi M, Haque A, You J, Lowen J, Soleimani M and Revzin A 2016 Acta Biomater. 34 125
    Kim C, Park K-S, Kim J, Jeong S-G and Lee C-S 2017 J. Chem. Technol. Biotechnol. 92 201
    Xu N, Yang H, Wei R, Pan S, Huang S, Xiao X, Wen H and Xue W 2019 Int. J. Biol. Macromol. 127 440
    Mu R-J, Ni Y, Wang L, Yuan Y, Yan Z, Pang J and Chen S 2017 Mater. Lett. 196 410
    Akhter K F, Mumin M A, Lui E K and Charpentier P A 2016 ACS Biomater. Sci. Eng. 2 96
    Zykwinska A et al 2019 Mar. Drugs 17 65
    Wang Y, Katyal P and Montclare J K 2019 Adv. Healthcare Mater. 8 1801374
    Shen Y, Levin A, Kamada A, Toprakcioglu Z, Rodriguez-Garcia M, Xu Y and Knowles T P J 2021 ACS Nano 15 5819
    Farokhi M, Mottaghitalab F, Fatahi Y, Khademhosseini A and Kaplan D L 2018 Trends Biotechnol. 36 907
    Holland C, Numata K, Rnjak-Kovacina J and Seib F P 2019 Adv. Healthcare Mater. 8 1800465
    Wongpinyochit T, Totten J D, Johnston B F and Seib F P 2019 Nanoscale Adv. 1 873
    Toprakcioglu Z and Knowles T P J 2021 Sci. Rep. 11 6673
    Liu Q, Jiang N, Liu D W, Ying G L, Shi Q S, Yetisen A K, Liu H F and Fan Y B 2018 Appl. Phys. Lett. 112 173701
    Liu X Z et al 2019 Macromol. Rapid Commun. 40 1800898
    Toprakcioglu Z, Levin A and Knowles T P J 2017 Biomacromolecules 18 3642
    Montoya N V, Peterson R, Ornell K J, Albrecht D R and Coburn J M 2020 Molecules 25 890
    Zhao X, Chen Z Y, Liu Y X, Huang Q, Zhang H D, Ji W, Ren J N, Li J S and Zhao Y J 2018 Adv. Healthcare Mater. 7 1801005
    Sun J, Chen J S, Liu K and Zeng H B 2021 Engineering 7 615
    Lu L, Fan S N, Geng L H, Yao X and Zhang Y P 2021 Chem. Eng. J. 405 126793
    Li S Y, Hang Y J, Ding Z Z, Lu Q, Lu G Z, Chen H and Kaplan D L 2020 ACS Biomater. Sci. Eng. 6 2847
    Lu L, Fan S N, Niu Q Q, Peng Q F, Geng L H, Yang G S, Shao H L, Hsiao B S and Zhang Y P 2019 ACS Sustainable Chem. Eng. 7 14765
    Li D, Jacobsen M M, Rim N G, Backman D, Kaplan D L and Wong J Y 2017 Biofabrication 9 025025
    Catoira M C, Fusaro L, di Francesco D, Ramella M and Boccafoschi F 2019 J. Mater. Sci. Mater. Med. 30 115
    Vanaei S, Parizi M S, Vanaei S, Salemizadehparizi F and Vanaei H R 2021 Eng. Regener. 2 1
    Ashokkumar M and Ajayan P M 2021 Int. Mater. Rev. 66 160
    Oosterlaken B M, Vena M P and de With G 2021 Adv. Mater. 33 2004418
    Yang G, Mahadik B, Choi J Y, Yu J R, Mollot T, Jiang B, He X and Fisher J P 2021 Acta Biomater. 121 204
    Hong G et al 2021 Adv. Mater. 33 2102624
    Wu C, Liu A, Chen S, Zhang X, Chen L, Zhu Y, Xiao Z, Sun J, Luo H and Fan H 2019 ACS Appl. Mater. Interfaces 11 22152
    Dasgupta A et al 2021 Acta Biomater. 128 186
    Piao Y, You H, Xu T, Bei H-P, Piwko I Z, Kwan Y Y and Zhao X 2021 Eng. Regener. 2 47
    Xu Y F, Qi R Z, Zhu H J, Li B, Shen Y, Krainer G, Klenerman D and Knowles T P J 2021 Adv. Mater. 33 2008670
    Xu Y, Jacquat R P B, Shen Y, Vigolo D, Morse D, Zhang S and Knowles T P J 2020 Small 16 2000432
    He C J, Wei X W, Liang T, Liu M X, Jiang D M, Zhuang L J and Wang P 2021 Adv. Healthcare Mater. 10 2001716
    Feng Q, Gao H, Wen H, Huang H, Li Q, Liang M, Liu Y, Dong H and Cao X 2020 Acta Biomater. 113 393
    Xiang L and Cui W 2021 J. Leather Sci. Eng. 3 3
    Zhao Z, Li G, Ruan H, Chen K, Cai Z, Lu G, Li R, Deng L, Cai M and Cui W 2021 ACS Nano 15 13041
    Yang J L, Han Y, Lin J W, Zhu Y, Wang F, Deng L F, Zhang H Y, Xu X Y and Cui W G 2020 Small 16 2004519
    Yang J L, Zhu Y, Wang F, Deng L F, Xu X Y and Cui W G 2020 Chem. Eng. J. 400 126004
    Han X Y, Sun M J, Chen B, Saiding Q, Zhang J Y, Song H L, Deng L F, Wang P, Gong W M and Cui W G 2021 Bioact. Mater. 6 1639
    Yang J, Liang J, Zhu Y, Hu M, Deng L, Cui W and Xu X 2021 Bioact. Mater. 6 4801
    Cheng R Y, Yan Y F, Liu H, Chen H, Pan G Q, Deng L F and Cui W G 2018 Appl. Mater. Today 12 294
    Yan J Q et al 2021 Small 17 2100479
    Zhao X, Liu S, Yildirimer L, Zhao H, Ding R H, Wang H N, Cui W G and Weitz D 2016 Adv. Funct. Mater. 26 2809
    Lee D and Cha C 2018 Pharmaceutics 10 229
    Lee D and Cha C 2020 Mater. Sci. Eng. C 112 110932
    Sheikholeslam M, Wright M E E, Jeschke M G and Amini-Nik S 2018 Adv. Healthcare Mater. 7 1700897
    Choi J R, Yong K W, Choi J Y and Cowie A C 2019 BioTechniques 66 40
    Seeto W J, Tian Y, Pradhan S, Kerscher P and Lipke E A 2019 Small 15 1902058
    Sharifi F, Patel B B, McNamara M C, Meis P J, Roghair M N, Lu M, Montazami R, Sakaguchi D S and Hashemi N N 2019 ACS Appl. Mater. Interfaces 11 18797
    Aykar S S, Reynolds D E, McNamara M C and Hashemi N N 2020 RSC Adv. 10 4095
    Dinh N-D et al 2020 Lab Chip 20 2756
    Nam C, Yoon J, Ryu S A, Choi C-H and Lee H 2018 ACS Appl. Mater. Interfaces 10 40366
    Lu X G et al 2020 Sci. Transl. Med. 12 eaaz6606
    Kasiewicz L N and Whitehead K A 2017 Biomater. Sci. 5 1962
    Li X Y and Jiang X Y 2018 Adv. Drug Del. Rev. 128 101
    Hoogendijk E et al 2020 ACS Appl. Mater. Interfaces 12 49335
    Agnoletti M, Rodriguez-Rodriguez C, Klodzinska S N, Esposito T V F, Saatchi K, Nielsen H M and Hafeli U O 2020 ACS Nano 14 6693
    Lin Z J et al 2018 Biomaterials 174 1
    Zhang H, Hao L Z, Pan J A, Gao Q, Zhang J F, Kankala R K, Wang S B, Chen A Z and Zhang H L 2021 J. Control. Release 329 286
    Wu H C, Shen L, Zhu Z, Luo X S, Zhai Y S, Hua X B, Zhao S C, Cen L and Zhang Z B 2020 Chem. Eng. J. 393 124649
    Liu X Z, Chen M M, Luo J C, Zhao H, Zhou X C, Gu Q, Yang H L, Zhu X S, Cui W G and Shi Q 2021 Biomaterials 276 121037
    Sharifi F, Kurteshi D and Hashemi N 2016 J. Mech. Behav. Biomed. Mater. 61 530
    Cui T, Yu J, Li Q, Wang C-F, Chen S, Li W and Wang G 2020 Adv. Mater. 32 2000982
    Nofar M, Sacligil D, Carreau P J, Kamal M R and Heuzey M-C 2019 Int. J. Biol. Macromol. 125 307
    Huang Q, He F, Yu J, Zhang J, Du X, Li Q, Wang G, Yu Z and Chen S 2021 J. Mater. Chem. B 9 2727
    Ekanem E E, Zhang Z and Vladisavljevi´c G T 2017 J. Colloid Interface Sci. 498 387
    Bergström J S and Hayman D 2016 Ann. Biomed. Eng. 44 330
    Xu Y C et al 2020 Adv. Funct. Mater. 30 2006333
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