Volume 2 Issue 4
December  2023
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Yue Niu, Ze Qin, Ying Zhang, Chao Chen, Sha Liu, Hu Chen. Expanding the potential of biosensors: a review on organic field effect transistor (OFET) and organic electrochemical transistor (OECT) biosensors[J]. Materials Futures, 2023, 2(4): 042401. doi: 10.1088/2752-5724/ace3dd
Citation: Yue Niu, Ze Qin, Ying Zhang, Chao Chen, Sha Liu, Hu Chen. Expanding the potential of biosensors: a review on organic field effect transistor (OFET) and organic electrochemical transistor (OECT) biosensors[J]. Materials Futures, 2023, 2(4): 042401. doi: 10.1088/2752-5724/ace3dd
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Topical Review •
OPEN ACCESS

Expanding the potential of biosensors: a review on organic field effect transistor (OFET) and organic electrochemical transistor (OECT) biosensors

© 2023 The Author(s). Published by IOP Publishing Ltd on behalf of the Songshan Lake Materials Laboratory
Materials Futures, Volume 2, Number 4
  • Received Date: 2023-06-20
  • Accepted Date: 2023-07-03
  • Publish Date: 2023-08-04
doi: 10.1088/2752-5724/ace3dd
  • 1.

    School of Physical Sciences, Great Bay University, Dongguan 523000, People’s Republic of China

  • 2.

    Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, People’s Republic of China

  • 3.

    Hunan Institute of Metrology and Test, Changsha 410014, People’s Republic of China

  • Yue Niu and Ze Qin contributed equally to this work.

More Information
    Abstract
  • Organic electronics have gained significant attention in the field of biosensors owing to their immense potential for economical, lightweight, and adaptable sensing devices. This review explores the potential of organic electronics-based biosensors as a revolutionary technology for biosensing applications. The focus is on two types of organic biosensors: organic field effect transistor (OFET) and organic electrochemical transistor (OECT) biosensors. OFET biosensors have found extensive application in glucose, DNA, enzyme, ion, and gas sensing applications, but suffer from limitations related to low sensitivity and selectivity. On the other hand, OECT biosensors have shown superior performance in sensitivity, selectivity, and signal-to-noise ratio, owing to their unique mechanism of operation, which involves the modulation of electrolyte concentration to regulate the conductivity of the active layer. Recent advancements in OECT biosensors have demonstrated their potential for biomedical and environmental sensing, including the detection of neurotransmitters, bacteria, and heavy metals. Overall, the future directions of OFET and OECT biosensors involve overcoming these challenges and developing advanced devices with improved sensitivity, selectivity, reproducibility, and stability. The potential applications span diverse fields including human health, food analysis, and environment monitoring. Continued research and development in organic biosensors hold great promise for significant advancements in sensing technology, opening up new possibilities for biomedical and environmental applications.
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  • [1]
    Chen H, et al 2017 Dithiopheneindenofluorene (TIF) semiconducting polymers with very high mobility in field-effect transistors Adv. Mater. 29 1702523 doi: 10.1002/adma.201702523
    [2]
    Zhang T, Ren W, Xiao F, Li J, Zu B, Dou X 2022 Engineered olfactory system for in vitro artificial nose Eng. Regen. 3 427-39 doi: 10.1016/j.engreg.2022.09.003
    [3]
    Tian L, Jackson K, Chan M, Saif A, He L, Didar T F, Hosseinidoust Z 2022 Phage display for the detection, analysis, disinfection, and prevention of Staphylococcus aureus Smart Med. 1 e20220015 doi: 10.1002/SMMD.20220015
    [4]
    Katz E, Willner I 2004 Biomolecule-functionalized carbon nanotubes: applications in nanobioelectronics ChemPhysChem 5 1084-104 doi: 10.1002/cphc.200400193
    [5]
    Luo L, Liu Z 2022 Recent progress in organic field-effect transistor-based chem/bio-sensors View 3 20200115 doi: 10.1002/VIW.20200115
    [6]
    Basiric L, Mattana G, Mas-Torrent M 2022 Editorial: organic electronics: future trends in materials, fabrication techniques and applications Front. Phys. 10 307 doi: 10.3389/fphy.2022.888155
    [7]
    Forrest S R 2004 The path to ubiquitous and low-cost organic electronic appliances on plastic Nature 428 911-8 doi: 10.1038/nature02498
    [8]
    Marks A, Griggs S, Gasparini N, Moser M 2022 Organic electrochemical transistors: an emerging technology for biosensing Adv. Mater. Interfaces 9 2102039 doi: 10.1002/admi.202102039
    [9]
    Bai L, Elsegui C G, Li W, Yu P, Fei J, Mao L 2019 Biological applications of organic electrochemical transistors: electrochemical biosensors and electrophysiology recording Front. Chem. 7 313 doi: 10.3389/fchem.2019.00313
    [10]
    Surya S G, Raval H N, Ahmad R, Sonar P, Salama K N, Rao V R 2019 Organic field effect transistors (OFETs) in environmental sensing and health monitoring: a review TrAC, Trends Anal. Chem. 111 27-36 doi: 10.1016/j.trac.2018.11.027
    [11]
    Yuvaraja S, Nawaz A, Liu Q, Dubal D, Surya S G, Salama K N, Sonar P 2020 Organic field-effect transistor-based flexible sensors Chem. Soc. Rev. 49 3423-60 doi: 10.1039/C9CS00811J
    [12]
    Dimov I B, Moser M, Malliaras G G, McCulloch I 2022 Semiconducting polymers for neural applications Chem. Rev. 122 4356-96 doi: 10.1021/acs.chemrev.1c00685
    [13]
    Feng K, et al 2021 Fused bithiophene imide dimer-based n-type polymers for high-performance organic electrochemical transistors Angew. Chem., Int. Ed. 60 24198-205 doi: 10.1002/anie.202109281
    [14]
    Wu R, Matta M, Paulsen B D, Rivnay J 2022 Operando characterization of organic mixed ionic/electronic conducting materials Chem. Rev. 122 4493-551 doi: 10.1021/acs.chemrev.1c00597
    [15]
    Koklu A, Ohayon D, Wustoni S, Druet V, Saleh A, Inal S 2022 Organic bioelectronic devices for metabolite sensing Chem. Rev. 122 4581-635 doi: 10.1021/acs.chemrev.1c00395
    [16]
    Mariano A, Lubrano C, Bruno U, Ausilio C, Dinger N B, Santoro F 2022 Advances in cell-conductive polymer biointerfaces and role of the plasma membrane Chem. Rev. 122 4552-80 doi: 10.1021/acs.chemrev.1c00363
    [17]
    Kukhta N A, Marks A, Luscombe C K 2022 Molecular design strategies toward improvement of charge injection and ionic conduction in organic mixed ionic-electronic conductors for organic electrochemical transistors Chem. Rev. 122 4325-55 doi: 10.1021/acs.chemrev.1c00266
    [18]
    Zhu M, Li P, Li J-L, Lei T 2022 Molecular packing and film morphology control in organic electrochemical transistors Mol. Syst. Des. Eng. 7 6-20 doi: 10.1039/D1ME00134E
    [19]
    Rivnay J, Inal S, Salleo A, Owens R M, Berggren M, Malliaras G G 2018 Organic electrochemical transistors Nat. Rev. Mater. 3 17086 doi: 10.1038/natrevmats.2017.86
    [20]
    Feng K, Guo H, Sun H, Guo X 2021 N-type organic and polymeric semiconductors based on bithiophene imide derivatives Acc. Chem. Res. 54 3804-17 doi: 10.1021/acs.accounts.1c00381
    [21]
    Blom P W M 2020 Polymer electronics: to be or not to be? Adv. Mater. Technol. 5 2000144 doi: 10.1002/admt.202000144
    [22]
    Wadsworth A, et al 2020 Modification of indacenodithiophene-based polymers and its impact on charge carrier mobility in organic thin-film transistors J. Am. Chem. Soc. 142 652-64 doi: 10.1021/jacs.9b09374
    [23]
    Chen H, et al 2019 The effect of ring expansion in thienobenzo[b]indacenodithiophene polymers for organic field-effect transistors J. Am. Chem. Soc. 141 18806-13 doi: 10.1021/jacs.9b09367
    [24]
    Chen H, et al 2021 Acene ring size optimization in fused lactam polymers enabling high n-type organic thermoelectric performance J. Am. Chem. Soc. 143 260-8 doi: 10.1021/jacs.0c10365
    [25]
    Xiao M, et al 2021 Charge transport physics of a unique class of rigid-rod conjugated polymers with fused-ring conjugated units linked by double carbon-carbon bonds Sci. Adv. 7 eabe5280 doi: 10.1126/sciadv.abe5280
    [26]
    Feng K, et al 2019 Fluorine-substituted dithienylbenzodiimide-based n-type polymer semiconductors for organic thin-film transistors ACS Appl. Mater. Interfaces 11 35924-34 doi: 10.1021/acsami.9b13138
    [27]
    Zhou Q, Wang M, Yagi S, Minami T 2021 Extended gate-type organic transistor functionalized by molecularly imprinted polymer for taurine detection Nanoscale 13 100-7 doi: 10.1039/D0NR06920E
    [28]
    Didier P, Lobato-Dauzier N, Clment N, Genot A J, Sasaki Y, Leclerc , Minamiki T, Sakai Y, Fujii T, Minami T 2020 Microfluidic system with extended-gate-type organic transistor for real-time glucose monitoring ChemElectroChem 7 1332-6 doi: 10.1002/celc.201902013
    [29]
    Tang W, Fu Y, Huang Y, Li Y, Song Y, Xi X, Yu Y, Su Y, Yan F, Guo X 2022 Solution processed low power organic field-effect transistor bio-chemical sensor of high transconductance efficiency npj Flex. Electron. 6 18 doi: 10.1038/s41528-022-00149-9
    [30]
    Liu J, Agarwal M, Varahramyan K 2008 Glucose sensor based on organic thin film transistor using glucose oxidase and conducting polymer Sens. Actuators B 135 195-9 doi: 10.1016/j.snb.2008.08.009
    [31]
    Elkington D, Belcher W J, Dastoor P C, Zhou X J 2014 Detection of saliva-range glucose concentrations using organic thin-film transistors Appl. Phys. Lett. 105 043303 doi: 10.1063/1.4892012
    [32]
    Li T, Zhong G, Fu R, Yang Y 2010 Synthesis and characterization of Nafion/cross-linked PVP semi-interpenetrating polymer network membrane for direct methanol fuel cell J. Membr. Sci. 354 189-97 doi: 10.1016/j.memsci.2010.02.038
    [33]
    Sun C, Wang X, Auwalu M A, Cheng S, Hu W 2021 Organic thin film transistors-based biosensors EcoMat 3 e12094 doi: 10.1002/eom2.12094
    [34]
    Khan H U, Roberts M E, Johnson O, Frch R, Knoll W, Bao Z 2010 In situ, label-free DNA detection using organic transistor sensors Adv. Mater. 22 4452-6 doi: 10.1002/adma.201000790
    [35]
    Lai S, Demelas M, Casula G, Cosseddu P, Barbaro M, Bonfiglio A 2013 Ultralow voltage, OTFT-based sensor for label-free DNA detection Adv. Mater. 25 103-7 doi: 10.1002/adma.201202996
    [36]
    Minami T, Sasaki Y, Minamiki T, Wakida S-I, Kurita R, Niwa O, Tokito S 2016 Selective nitrate detection by an enzymatic sensor based on an extended-gate type organic field-effect transistor Biosens. Bioelectron. 81 87-91 doi: 10.1016/j.bios.2016.02.036
    [37]
    Ohshiro K, Sasaki Y, Minami T 2023 An extended-gate-type organic transistor-based enzymatic sensor for dopamine detection in human urine Talanta Open 7 100190 doi: 10.1016/j.talo.2023.100190
    [38]
    Kumar A, Meunier-Prest R, Bouvet M 2020 Organic heterojunction devices based on phthalocyanines: a new approach to gas chemosensing Sensors 20 4700 doi: 10.3390/s20174700
    [39]
    Yuvaraja S, Bhyranalyar V N, Bhat S A, Surya S G, Yelamaggad C V, Salama K N 2021 A highly selective electron affinity facilitated H2S sensor: the marriage of tris(keto-hydrazone) and an organic field-effect transistor Mater. Horiz. 8 525-37 doi: 10.1039/D0MH01420F
    [40]
    Oh S, Khan M R R, Choi G, Seo J, Park E, An T K, Park Y D, Lee H S 2021 Advanced organic transistor-based sensors utilizing a solvatochromic medium with twisted intramolecular charge-transfer behavior and its application to ammonia gas detection ACS Appl. Mater. Interfaces 13 56385-93 doi: 10.1021/acsami.1c15116
    [41]
    Hou S, Zhuang X, Fan H, Yu J 2021 Grain boundary control of organic semiconductors via solvent vapor annealing for high-sensitivity NO2 detection Sensors 21 226 doi: 10.3390/s21010226
    [42]
    Sagdullina D, Lukashkin N, Parfenov A, Lyssenko K, Troshin P 2020 Highly sensitive OFET-based gas sensors using fluorinated naphthalenediimide semiconductor films Synth. Met. 260 116289 doi: 10.1016/j.synthmet.2019.116289
    [43]
    Zhang C, Chen P, Hu W 2015 Organic field-effect transistor-based gas sensors Chem. Soc. Rev. 44 2087-107 doi: 10.1039/C4CS00326H
    [44]
    Zhang S, Zhao Y, Du X, Chu Y, Zhang S, Huang J 2019 Gas sensors based on nano/microstructured organic field-effect transistors Small 15 1805196 doi: 10.1002/smll.201805196
    [45]
    Sun H, Gerasimov J, Berggren M, Fabiano S 2018 N-type organic electrochemical transistors: materials and challenges J. Mater. Chem. C 6 11778-84 doi: 10.1039/C8TC03185A
    [46]
    Zhao D, et al 2019 Polymer gels with tunable ionic Seebeck coefficient for ultra-sensitive printed thermopiles Nat. Commun. 10 1093 doi: 10.1038/s41467-019-08930-7
    [47]
    Xia Y, Zhang W, Ha M, Cho J H, Renn M J, Kim C H, Frisbie C D 2010 Printed sub-2 V gel-electrolyte-gated polymer transistors and circuits Adv. Funct. Mater. 20 587-94 doi: 10.1002/adfm.200901845
    [48]
    Rivnay J, et al 2015 High-performance transistors for bioelectronics through tuning of channel thickness Sci. Adv. 1 e1400251 doi: 10.1126/sciadv.1400251
    [49]
    Khodagholy D, et al 2013 High transconductance organic electrochemical transistors Nat. Commun. 4 2133 doi: 10.1038/ncomms3133
    [50]
    Giovannitti A, Sbircea D-T, Inal S, Nielsen C B, Bandiello E, Hanifi D A, Sessolo M, Malliaras G G, McCulloch I, Rivnay J 2016 Controlling the mode of operation of organic transistors through side-chain engineering Proc. Natl Acad. Sci. 113 12017-22 doi: 10.1073/pnas.1608780113
    [51]
    Bucella S G, Luzio A, Gann E, Thomsen L, McNeill C R, Pace G, Perinot A, Chen Z, Facchetti A, Caironi M 2015 Macroscopic and high-throughput printing of aligned nanostructured polymer semiconductors for MHz large-area electronics Nat. Commun. 6 8394 doi: 10.1038/ncomms9394
    [52]
    Bernards D A, Malliaras G G 2007 Steady-state and transient behavior of organic electrochemical transistors Adv. Funct. Mater. 17 3538-44 doi: 10.1002/adfm.200601239
    [53]
    Braendlein M, Lonjaret T, Leleux P, Badier J-M, Malliaras G G 2017 Voltage amplifier based on organic electrochemical transistor Adv. Sci. 4 1600247 doi: 10.1002/advs.201600247
    [54]
    Nishizawa M, Matsue T, Uchida I 1992 Penicillin sensor based on a microarray electrode coated with pH-responsive polypyrrole Anal. Chem. 64 2642-4 doi: 10.1021/ac00045a030
    [55]
    Gao N, Yu J, Tian Q, Shi J, Zhang M, Chen S, Zang L 2021 Application of PEDOT:PSS and its composites in electrochemical and electronic chemosensors Chemosensors 9 79 doi: 10.3390/chemosensors9040079
    [56]
    Braendlein M, Pappa A-M, Ferro M, Lopresti A, Acquaviva C, Mamessier E, Malliaras G G, Owens R M 2017 Lactate detection in tumor cell cultures using organic transistor circuits Adv. Mater. 29 1605744 doi: 10.1002/adma.201605744
    [57]
    Zhang L, Li Q, Li Z, Du Z, Hong X, Qiu L 2020 An enzyme biosensor based on organic transistors for recognizing -amino acid enantiomers J. Electrochem. Soc. 167 067517 doi: 10.1149/1945-7111/ab819d
    [58]
    Lin P, Yan F, Yu J, Chan H L W, Yang M 2010 The application of organic electrochemical transistors in cell-based biosensors Adv. Mater. 22 3655-60 doi: 10.1002/adma.201000971
    [59]
    Wei W, Xiao K, Tao M, Nie L, Liu D, Ke S, Zeng X, Hu Z, Lin P, Zhang Y 2017 A novel organic electrochemical transistor-based platform for monitoring the senescent green vegetative phase of Haematococcus pluvialis cells Sensors 17 1997 doi: 10.3390/s17091997
    [60]
    Macchia E, Romele P, Manoli K, Ghittorelli M, Magliulo M, Kovcs-Vajna Z M, Torricelli F, Torsi L 2018 Ultra-sensitive protein detection with organic electrochemical transistors printed on plastic substrates Flex. Print. Electron. 3 034002 doi: 10.1088/2058-8585/aad0cb
    [61]
    Fu Y, Wang N, Yang A, Law H K-W, Li L, Yan F 2017 Highly sensitive detection of protein biomarkers with organic electrochemical transistors Adv. Mater. 29 1703787 doi: 10.1002/adma.201703787
    [62]
    Chen C, Song Q, Lu W, Zhang Z, Yu Y, Liu X, He R 2021 A sensitive platform for DNA detection based on organic electrochemical transistor and nucleic acid self-assembly signal amplification RSC Adv. 11 37917-22 doi: 10.1039/D1RA07375C
    [63]
    Sensi M, Migatti G, Beni V, D’Alvise T M, Weil T, Berto M, Greco P, Imbriano C, Biscarini F, Bortolotti C A 2022 Monitoring DNA hybridization with organic electrochemical transistors functionalized with polydopamine Macromol. Mater. Eng. 307 2100880 doi: 10.1002/mame.202100880
    [64]
    Pappa A M, Ohayon D, Giovannitti A, Maria I P, Savva A, Uguz I, Rivnay J, McCulloch I, Owens R M, Inal S 2018 Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor Sci. Adv. 4 eaat0911 doi: 10.1126/sciadv.aat0911
    [65]
    Bolin M H, Svennersten K, Nilsson D, Sawatdee A, Jager E W H, Richter-Dahlfors A, Berggren M 2009 Active control of epithelial cell-density gradients grown along the channel of an organic electrochemical transistor Adv. Mater. 21 4379-82 doi: 10.1002/adma.200901191
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